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Keywords Ferroptosis tumor therapy Indole-3-aldehyde AHR JNK/JUN DNA damage Lactobacillus reuteri 1 Introduction Ferroptosis is a regulated, non-apoptotic, iron-dependent cell death characterized by excessive lipid peroxidation and a distinct redox-metabolic signature1,2. Ferrous iron catalyzes the formation of reactive oxygen species (ROS) via Fenton chemistry, amplifying membrane damage through uncontrolled phospholipid hydroperoxide generation.
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