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Rui-ying Guo on Muck Rack

Rui-ying Guo

As seen in: Nature
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Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway

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By Kan Wu, Peng Wang, Jong-Heon Kim, Kyoungho Suk, Yuan Wang, Xiang-Dong Du, Long-Tai Zheng, Zhi-rou Xu, Rui-ying Guo, Jia-wei Ou-Yang, Zhong-qiang Cao, Hui-cui Yang, Xiao-hu Zhang, Xue-chu Zhen
| Nature Verified
Abstract The Sonic Hedgehog (Shh)–Gli1 signaling axis is essential for neuronal development, cell proliferation and homeostasis. However, its roles in microglial activation and neuroinflammation remain poorly defined. Here, we report that Shh is expressed in neurons and astrocytes and is markedly upregulated in the substantia nigra of MPTP-challenged Parkinson’s disease (PD) mouse models.
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