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Ruicen He on Muck Rack

Ruicen He

As seen in: Nature
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Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate

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By Victoire Fort, Gabriel Khelifi, Valerie Watters, Melanie Pye, Nobuko Yamanaka, Jeremy Loehr, Jean-Philippe Lambert, Jeffrey L. Wrana, Samer Hussein, Ruicen He, Marina Gertsenstein, Émeline I. J. Lelong, Victoria Micha, Yojiro Yamanaka
| Nature Verified
Abstract Development of long-read RNA sequencing technologies has paved the way to the exploration of RNA isoform diversity and its relevance in regulating cell fate. However, identifying new functional isoforms is still very difficult. Here, we leverage long-read RNA sequencing to study changes in isoforms during somatic cell reprogramming and identify novel isoforms occurring throughout cell state transitions.
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