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Ruiying Ho on Muck Rack

Ruiying Ho

As seen in: BioRxiv
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Articles

Pancreatic islet alpha cells regulate microtubule stability in neighboring beta cells to tune insulin secretion and induce functional heterogeneity in individual mouse and human islets

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By Kung-Hsien Ho, Syed Nooruzuha Barmaver, Mahircan Yagan, Ruiying Ho
| BioRxiv
Abstract We have reported that the microtubule (MT) network in beta cells attenuates this function by withdrawing insulin secretory granules (ISGs) away from the plasma membrane. Thus, high glucose-induced MT remodeling is required for robust glucose-stimulated insulin secretion (GSIS). We now show that alpha-cell secreted hormones, Gcg and/or Glp1, regulate the MT stability in beta cells.
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