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Ruiying Qiu on Muck Rack

Ruiying Qiu

As seen in: Nature
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Articles

Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids - Nature Communications

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By Ruiying Qiu, Huisi Huang, Junxi Chi, Longwei Gao, Qilin Gao, Min Li, Menghao Cai, Haishuang Yu, Shijie Wang, Zhilan Qian, Minchuan Jiang, Yu Chi Liu, Bo Chen, Yang Zhou, Zhi-Min Zhang, Jian-Bo Wang
| Nature Verified
Abstract C-prenylated flavonoids possess notable pharmaceutical potential, but their production is hindered by the challenging selective prenylation of their unstable polyphenolic cores. Natural prenyltransferases offer a direct route but suffer from low activity and incomplete mechanistic understanding. Here, we report a directed evolution strategy to reshape the active pocket of the prenyltransferase AtaPT, uncovering an aromatic cage that governs both regioselectivity and donor specificity.
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