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Ruiying Xiao on Muck Rack

Ruiying Xiao

As seen in: The BMJ
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Non-enzymatic Rnaseh2c orchestrates proliferating macrophage-driven immunosuppression and HCC progression via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8 + T ex infiltration: a novel therapeutic paradigm with “Rnaseh2c-In1” inhibitor

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By Zengbin Wang, Mengxin Liu, Ruiying Xiao
| The BMJ Verified
It is known that macrophages are crucial components in the hepatocellular carcinoma (HCC) tumor microenvironment, with established roles for M1 and M2 subtypes, and that CD8+ exhausted T cell (Tex) contribute to tumor progression. However, the existence of a distinct proliferating macrophage subset and its specific regulatory mechanisms remains unclear.
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