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Vaccinia-related kinase 2 confers pancreatic cancer with gemcitabine resistance through TPI1-driven aerobic glycolysis
Abstract Gemcitabine(GEM)-based chemotherapy is considered the first-line regimen for pancreatic cancer(PC), but the poor responsiveness and chemoresistance greatly limit its application. Metabolic reprogramming, especially aerobic glycolysis, which is regulated by glycolytic enzymes, is closely associated with the malignant behavior of PC.
Temporin-Derived Peptides Protect Mice against Enterohemorrhagic Escherichia coli O157:H7 Infection by Inhibiting Inflammation and Enhancing the Intestinal Epithelial Barrier Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJuly 8, 2026 Temporin-Derived Peptides Protect Mice against Enterohemorrhagic Escherichia coli O157:H7 Infection by Inhibiting Inflammation and Enhancing the Intestinal Epithelial Barrier Click to copy article linkArticle link copied! Jing Chen Jing Chen Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China Hainan Provincial Center for Animal Disease Prevention and...
Rapid and Continuous Directed Evolution in Vibrio natriegens Utilizing an In Vivo Hypermutation System Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Research ArticleJune 26, 2026 Rapid and Continuous Directed Evolution in Vibrio natriegens Utilizing an In Vivo Hypermutation System Click to copy article linkArticle link copied! Ruiying Zhu Ruiying Zhu Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310058, China Zhejiang Key Laboratory of Intelligent Manufacturing for Functional Chemicals,...
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