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Ruizhan Tong on Muck Rack

Ruizhan Tong

As seen in: Nature
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Articles

SBRT embedded in low-dose RT plus αPD-1 (immuno-EclipseRT, iERT) elicits CD8 + T cell immunity against bulky tumors via an IFN-I/NK/DC axis

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By Ren Luo, Min Yu, Kai Kang, Yufeng Zhang, Shanghai Liu, Zhuoran Yao, Xuanwei Zhang, Zhou Su, Linglu Yi, Hui Wang, Wenhao Zhao, Yue Zheng, Guo Lin, Feifei Na, MeiJuan Huang, Bingwen Zou, Long Bai, Renming Zhong, Di Yan, Gabriele Niedermann, Jianxin Xue, You Lu, Zichong Peng, Shuangsi Liao, Ruizhan Tong
| Nature Verified
Abstract Bulky tumors remain challenging to treat, and immune checkpoint inhibitors (ICIs), alone or combined with conventional radiotherapy (RT), yield limited efficacy. We present EclipseRT (ERT), an RT technique that delivers low-dose RT (LDRT) to the gross tumor volume (GTV) and stereotactic body RT (SBRT) to selected subvolume(s) within the GTV. Combined with ICIs (iERT), this approach achieves marked control of bulky tumors through the coordinated activity of NK and CD8⁺ T cells.
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