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Ruli Ge

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Articles

AS-IV attenuates nigral NLRP3 inflammasome in a Parkinson’s disease mouse model via gut microbiota

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By Jinfeng Cai, Man Wang, Yifei You, Fengjiao Sun, Mengdi Wang, Nan Wang, Rui Wang, Kan Zhang, Hongcai Wang, Ruli Ge
| Nature Verified
Abstract Astragaloside IV (AS-IV) neuroprotection against rotenone (ROT)-induced Parkinson’s pathology was examined via microbiota-gut-brain axis mechanisms. Methods included intraperitoneal AS-IV, fecal microbiota transplantation (FMT) from AS-IV-treated mice, and AS-IV-modulated microbiota transplantation. Substantia nigra dopaminergic neurons/microglia were evaluated by confocal imaging, while NLRP3, caspase-1, IL-1β, and α-synuclein (α-syn) levels were quantified via Western blot.
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