Runling Shen on Muck Rack

Runling Shen

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Articles

STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1 - Oncogene

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By Xudong Jia, Jiankai Liang, Wenbo Zhu, Qinfen Zhang, Deli Song, Runling Shen
| Nature Verified
Abstract Oncolytic viruses are emerging as promising anticancer agents. Although the essential biological function of N-glycosylation on viruses are widely accepted, roles of N-glycan and glycan-processing enzyme in oncolytic viral therapy are remain elusive. Here, via cryo-EM analysis, we identified three distinct N-glycans on the envelope of oncolytic virus M1 (OVM) as being necessary for efficient receptor binding.
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