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Submitted: 27 October 2026 You are already at the latest version Leptin receptor (LepR) signaling contributes to energy homeostasis and inflammatory responses, making LepR antagonism a potential anti-inflammatory strategy. Although H6-derived antibody ligands exhibit LepR agonistic activity, the pharmacological properties of H6 in a full-length immunoglobulin G format (H6-IgG) remain unclear.
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