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Runumi Baro on Muck Rack

Runumi Baro

As seen in: BioRxiv, Stem Cell Reports
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Articles

The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages

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By Hemant Naik, Runumi Baro, Amritesh Sarkar, Muralidhar Nayak, Kartik Sunagar, Srimonta Gayen
| Stem Cell Reports Verified
Keywords X-chromosome inactivation m6A -RNA methylation Xist embryonic stem cells ESC epiblast stem cells EpiSC trophoblast stem cells TSC extraembryonic endoderm stem cells XEN Introduction In the course of evolution, the Y chromosome underwent massive degradation through gene-loss events (Bachtrog, 2013; Graves, 2016; Lahn and Page, 1999). This rendered male-specific monoallelic expression of X-linked genes in contrast to biallelic expression from the autosomes.
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Role of m6A RNA methylation in dosage compensation

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By Hemant Naik, Runumi Baro, Amritesh Sarkar, Muralidhar Nayak M
| BioRxiv
Abstract In therian mammals, inactivation of one of the X-chromosomes in female cells (XX) balances the dosage of X-linked gene expression between the sexes, resulting in monoallelic expression of X-linked genes in females similar to males (XY). Therefore, it creates a dosage imbalance for X-linked genes with respect to the biallelically expressing autosomal genes (AA).
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Deletion of Xist upstream sequences alters TAD interactions and leads to defects in Xist coating and expression

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By Sudeshna Majumdar, Lakshmi Sowjanya Bammidi, Hemant Naik, Runumi Baro
| BioRxiv
Abstract The topological organization of the genome plays an important role in regulating gene expression. However, the connection between the two remains poorly understood. X chromosome inactivation is a unique model system to explore the interlink between topologically associated domains (TADs) and gene expression. TADs are largely lost upon X inactivation, and the inactive X gets bipartitely reorganized into two large mega domains.
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