Ruomei Gong on Muck Rack

Ruomei Gong

As seen in: Nature
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Articles

Human angiotensin‑converting enzyme 2‑specific benzothiazole-based allosteric inhibitor against pan‑sarbecoviruses

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By Li N Liu, Jinxin Bai, Runhong Zhou, Yao Ma, Dongyan Zhou, Terrence Tsz-Tai Yuen, Wenwu Liu, Wenjun Yu, Jianxin Duan, Xinhua Liu, Ka-Yi Kwan, Feifei Liu, Zhenglong Du, Pui Wang, Mengxiao Luo, Dawei Yang, Hin Chu, Zhiwei Chen, Gang Liu, Pok Man Lai, Jingjia Ye, Ruomei Gong, Tsz Tung Lee, Kong Hung Sze
| Nature
Abstract Emerging SARS‑CoV‑2 variants and related zoonotic sarbecoviruses rely on ACE2 for cell entry, motivating host‑directed antivirals that block spike-ACE2 interaction. Here, we characterize MB‑32, a benzothiazole small molecule that binds ACE2, selectively disrupts binding of SARS‑CoV‑2 spike receptor‑binding domain to ACE2, and preserves ACE2 enzymatic activity across species.
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