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Articles by Rupert Ecker
Correction: Editorial: Innovative organoid co-culture systems for enhanced precision medicine in cancer and beyond
A Correction on Editorial: Innovative organoid co-culture systems for enhanced precision medicine in cancer and beyond by Glaser, T., Ecker, R., and Ritter, U. (2026). Front. Med. 13:1871721. doi: 10.3389/fmed.2026.1871721 Affiliation “Leibniz Institute for Immunotherapy (LIT), Regensburg, Germany” was omitted for author [Uwe Ritter]. This affiliation has now been added for author [Uwe Ritter].
Editorial: Innovative organoid co-culture systems for enhanced precision medicine in cancer and beyond
Introduction Complex organoid co-culture systems that resemble tissue microenvironments are emerging as a powerful model for precision-medicine. Despite intrinsic in vitro limitations, patient-derived three-dimensional models closely recapitulate tissue architecture, cellular heterogeneity, and microenvironmental interactions.
A Fusion-Based Multiomics Classification Approach for Enhanced Gene Discovery in Non-Small Cell Lung Cancer
The authors have declared no competing interest. This study was partly funded by the Austrian Research Promotion Agency (FFG), project no. 895420. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer - Nature Communications
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Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates prostate cancer pathogenesis.
By Joan Röhl, Johanna Schleutker, Kenneth Muir, Henrik Grönberg, Nora Pashayan, Demetrius Albanes, Alicja Wolk, Robert MacInnis, Ana Francisca Vega Verified, Børge G Nordestgaard, Hermann Brenner, Marija Gamulin, Frank Claessens, Christel Häggström, Tokhir Dadaev, Mark Brook, Amanda B. Spurdle, Hannu Koistinen, Zsofia Kote-Jarai, Robert Klein, Hans Lilja, Rupert Ecker, Rosalind A. Eeles, Judith Clements, Karina Dalsgaard Sorensen, Ann-Charlotte Rönn
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Nature
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Community-developed checklists for publishing images and image analyses - Nature Methods
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Abstract Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However, for scientists wishing to publish obtained images and image-analysis results, there are currently no unified guidelines for best practices. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret.
By Christopher Schmied, Michael Nelson, Sergiy Avilov, Gert-Jan Bakker, Cristina Bertocchi, Johanna Bischof, Ulrike Boehm, Jan Brocher, Mariana Carvalho, Jana Christopher, Beth Cimini, Eduardo Conde-Sousa, Michael Ebner, Rupert Ecker, Kevin W. Eliceiri, Julia Fernandez-Rodriguez, Nathalie Gaudreault, Laurent Gelman, David Grunwald, Tingting Gu, Nadia Halidi, Mathias Hammer, Matthew Hartley, Marie Held, Florian Jug, Ayse Koksoy, Judith Lacoste, Sylvia Le Dévédec, Sylvie Le Guyader, Gabriel Martins, Aastha Mathur, Kota Miura, Paula Montero Llopis, Adam C. Parslow, Alex Payne-Dwyer, Laure Plantard, Ryan Scott, Arne Seitz, Olaf Selchow, Ved P. Sharma, Martin Spitaler, Sathya Srinivasan, Caterina Strambio-De-Castillia, Douglas Taatjes, Christian Tischer
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Nature
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Trapalyzer: a computer program for quantitative analyses in fluorescent live-imaging studies of neutrophil extracellular trap formation
Michał Aleksander Ciach1*†, Grzegorz Bokota1,2†, Aneta Manda-Handzlik3†, Weronika Kuźmicka3, Urszula Demkow3 and Anna Gambin1* 1Faculty of Mathematics, Informatics and Mechanics, University of Warsaw, Warsaw, Poland 2Centre of New Technologies, University of Warsaw, Warsaw, Poland 3Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Medical University of Warsaw, Warsaw, Poland Neutrophil extracellular traps (NETs), pathogen-ensnaring structures formed by...
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