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Russell C. Rockne on Muck Rack

Russell C. Rockne

As seen in: Nature, Medscape, The Astronomical Journal, BioRxiv
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Articles

Integrating imaging and mathematical modeling to predict and optimize patient outcomes in oncology

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By Reshmi Patel, Ayesha Das, Aliya Anil, Gauri Patel, Ryan T Woodall, Chase Christenson, Guillermo Lorenzo, David A. Hormuth II, Russell C. Rockne, Vikram Adhikarla, Chengyue Wu, Thomas E. Yankeelov, Tarini Thiagarajan, Ernesto A. B. F. Lima
| Nature Verified
Abstract Biology-based mathematical models calibrated to patient-specific imaging data can accurately predict and optimize therapeutic response for individual cancer patients. We present the framework, motivation, and examples of using imaging data to calibrate mathematical models and predict patient outcomes. We then discuss patient-specific digital twins for optimizing interventions and outcomes.
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Overcoming vascular niche–mediated TKI resistance in acute myeloid leukemia through miR-126 inhibition

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By Sergio Branciamore, Ziang Chen, David E Frankhouser, Yu-Hsuan Fu, Jihyun Irizarry, Ya-Huei Kuo, Denis O’Meally, Bin Zhang, Guido Marcucci, Russell C. Rockne, David Basanta, Matthew Froid, Jennifer Rangel Ambriz
| Nature Verified
Abstract Acute myeloid leukemia (AML) is a hematologic malignancy originating in the bone marrow and often progressing to extramedullary sites. Despite advances in molecularly targeted therapies and hematopoietic stem cell transplantation, clinical outcomes remain poor. Tyrosine kinase inhibitors (TKIs) provide benefit to a subset of AML patients harboring FLT3-ITD mutations; however, relapse and resistance remain common.
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Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines

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By Maxim L. Kuznetsov, Russell C. Rockne, Sergio Branciamore, Andrei Rodin
| BioRxiv
Abstract The JAK-STAT signaling pathway is fundamental for immune system regulation. It involves phosphorylation of several types of STAT proteins in response to binding of cytokines to immune cell receptors. Traditionally, the immune signaling studies focus on measuring the levels of phosphorylated STATs (pSTATs) following individual cytokine application.
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