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As seen in: Respiratory Research, jhltonline.org
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Articles

Amniotic fluid-derived mesenchymal stem cells reduce inflammation and improve lung function following transplantation in a porcine model

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By Anna Niroomand, Rutgers Robert, New Brunswick
| jhltonline.org Verified
Abstract Lung transplantation is hindered by low donor lung utilization rates. Infectious complications are reasons to decline donor grafts due to fear of post-transplant primary graft dysfunction. Mesenchymal stem cells are a promising therapy currently investigated in treating lung injury. Full-term amniotic fluid-derived lung-specific mesenchymal stem cell treatment may regenerate damaged lungs.
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Integrin α10β1-selected mesenchymal stem cells reduced hypercoagulopathy in a porcine model of acute respiratory distress syndrome - Respiratory Research

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By New Brunswick, Xintela AB, Rutgers Robert
| Respiratory Research Verified
In this study, integrin α10β1-MSCs derived from human adipose tissue were administered to pigs with LPS-induced ARDS to determine the treatment effects and safety of integrin α10β1-MSCs on lung injury. The results show that MSC treatment was associated with decreased need for inotropic support over the experimental timeline along with an anticoagulative effect compared to the placebo group. Histological examination of biopsies taken from the treated group also showed fewer signs of injury.
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