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Articles by Rutulkumar Patel
Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed Antitumor Immunity in Head and Neck Squamous Cell Carcinoma
Clinical Cancer Research 10.1158/1078-0432.CCR-25-0112 Author MSS NF-E2-Related Factor 2, Animals, Mice, Radiation Tolerance, Humans, Squamous Cell Carcinoma of Head and Neck, Kelch-Like ECH-Associated Protein 1, Head and Neck Neoplasms, Tumor Microenvironment, Cell Line, Tumor, Disease Models, Animal, Gene Expression Regulation, Neoplastic, Signal Transduction yes Patel, Rutulkumar; Saab, Kalil; Luo, Lixia; et al., "Nrf2 Hyperactivation as a Driver of Radiotherapy Resistance and Suppressed...
Targeting glutamine metabolism improves sarcoma response to radiation therapy in vivo - Communications Biology
Abstract Diverse tumor metabolic phenotypes are influenced by the environment and genetic lesions. Whether these phenotypes extend to rhabdomyosarcoma (RMS) and how they might be leveraged to design new therapeutic approaches remains an open question. Thus, we utilized a Pax7Cre-ER-T2/+; NrasLSL-G12D/+; p53fl/fl (P7NP) murine model of sarcoma with mutations that most frequently occur in human embryonal RMS.
56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice
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Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus
ResearchIn-Press PreviewOncology Open Access | 10.1172/JCI149310 J Clin Invest. https://doi.org/10.1172/JCI149310. Copyright © 2023, Floyd et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas.
Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Metabolomics in cancer research and emerging applications in clinical oncology
Abstract Cancer has myriad effects on metabolism that include both rewiring of intracellular metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor microenvironment, and changes in normal tissue metabolism. With the recognition that fluorodeoxyglucose-positron emission tomography imaging is an important tool for the management of many cancers, other metabolites in biological samples have been in the spotlight for cancer diagnosis, monitoring, and therapy.
<i>Mlh1</i> deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure
Cancer-causing genome instability is a major concern during space travel due to exposure of astronauts to potent sources of high-linear energy transfer (LET) ionizing radiation. Hematopoietic stem cells (HSCs) are particularly susceptible to genotoxic stress, and accumulation of damage can lead to HSC dysfunction and oncogenesis.
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