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Abstract Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spinal direct current stimulation (tsDCS) in MDD. This was a double-blind, randomized, sham-controlled, parallel group, pilot clinical trial in unmedicated adults with moderate MDD.
Acosta-Galvan G. Yi C.X. van der Vliet Jhamandas J.H. Panula P. Angeles-Castellanos M. del Carmen B.M. Escobar C. Buijs R.M. Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior. Proc. Natl. Acad. Sci. U. S. A. 2011; 108: 5813-5818 Asakawa A. Inui A. Kaga T. Yuzuriha H. Nagata T. Ueno N. Makino S. Fujimiya M. Niijima A. Fujino M.A. Kasuga M. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin.
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