Ruveyda Ummugulsum Unal on Muck Rack

Ruveyda Ummugulsum Unal

As seen in: Nature
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Articles

Nebivolol as a potential adjunct therapy for sepsis-induced cardiac dysfunction: evidence from a rat model

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By Onural Ozhan, Azibe Yildiz, Feyzi Dogru, Mehmet Ertugrul Balkar, Zeynep Kucukakcali, Hakan Parlakpinar, Ruveyda Ummugulsum Unal, Elif Sude Balkaya, Ayse Maden, Ayse Yucekaya
| Nature Verified
Abstract Sepsis frequently leads to cardiac dysfunction driven by oxidative stress (OS), inflammation, and conduction abnormalities. Nebivolol (NEB), a selective β1-blocker with vasodilatory and antioxidant properties, has shown organ-protective effects in sepsis, but its cardiovascular role remains unclear. This study investigated the effects of NEB in cecal ligation and puncture (CLP)-induced sepsis in rats. Thirty-two rats were assigned to four groups: Sham, NEB, CLP, and NEB + CLP.
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