Ruzal Sitdikov

1 Introduction The cascade chemistry approach represents a powerful synthetic strategy within organic synthesis [1-3], wherein multiple bond-forming events occur sequentially under a single set of reaction conditions, without the need for isolation of intermediates. Cascade chemistry offers many advantages, including increased atom economy, reduced reaction times and purification steps, as well as reduced solvent usage, which all contribute to operational simplicity and improved sustainability.

Introduction Both within academic and industrial organic synthesis, chlorinated compounds are being extensively used as building blocks for the synthesis of different value-added products, such as bioactive compounds, fine chemicals, materials, natural products, and pharmaceuticals (Figure 1).1 Furthermore, strategic incorporations of chlorine atoms have been shown to significantly alter or even enhance the biological properties of small molecules intended for therapeutic applications.1d, 1f,...