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Articles by Ryan J. Farrell
A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions
Abstract The endoplasmic reticulum (ER) is an important regulator of Ca2+ in cells and dysregulation of ER calcium homeostasis can lead to numerous pathologies. Understanding how various pharmacological and genetic perturbations of ER Ca2+ homeostasis impacts cellular physiology would likely be facilitated by more quantitative measurements of ER Ca2+ levels that allow easier comparisons across conditions.
Astrocyte growth is driven by the Tre1/S1pr1 phospholipid-binding G protein-coupled receptor
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Local Sourcing of Secretory Proteins in Faraway Places
A recent paper by Carter et al. identifies a novel organelle, the ribosome-associated vesicle (RAV), that might serve as a portable, local factory for producing proteins destined for the secretory pathway. The appearance of RAVs in dendrites suggests they may serve to generate membrane and secreted proteins in distal processes.
Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission
Highlights • Synapses rely on activity-driven mitochondrial ATP synthesis under oxidative conditions • Mitochondrial Ca 2+ uptake is required to stimulate ATP synthesis in axons • The mitochondria Ca 2+ uptake threshold is lower in axons than in non-neuronal cells • MICU3 controls the Ca 2+ sensitivity of MCU in axonal mitochondria Summary The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function.
Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission
Abstract The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can switch from glycolytic to oxidative metabolism, but to do so, they rely on activity-driven presynaptic mitochondrial Ca2+ uptake to accelerate ATP production.
Sports Spotlight: Stevie Kraljic
By Ryan Farrell |  Posted: Wed 3:43 PM, Jun 26, 2019 BISMARCK, N.D. - Stevie Kraljic was very busy at Century High School. He played football, basketball and baseball for the Patriots. Cade Feeney was a teammate in all three sports.
Sports Spotlight: Ashley Hulm
By Ryan Farrell |  Posted: Wed 8:50 PM, May 22, 2019 BISMARCK, N.D. - Ashley Hulm stays very busy at Legacy High school. She helped the Sabers win their first state basketball championship, she was second in the state for the girls triple jump last year, and she's also a four-year letter winner in volleyball. Hulm plays three sports for the Legacy Sabers.
Sport Spotlight: Paxton Miller
By Ryan Farrell |  Posted: Wed 3:24 PM, May 15, 2019 BISMARCK, N.D. - When Paxton Miller's baseball career is over at Legacy High School, he'll be remembered as the most successful pitcher to go through the program so far. He's come a long way from his first time stepping onto the mound. "I got absolutely hammered my first few times as a sophomore. I was kind of scared because that was my first time ever pitching. A lot of it was mentally, I just had to be mentally focused.
Sports Spotlight: Mark Moriarty
By Ryan Farrell |  Posted: Wed 3:10 PM, May 01, 2019 BISMARCK, N.D. - Mark Moriarty came to the University of Mary after winning a national championship as the pitching coach for Augustana. With a handful of games left in his first season at the helm, the Marauders are reaping the benefits of his move to Bismarck. Moriarty was named the head baseball coach of the UMary Marauders, last summer. For Moriarty, it was an opportunity he has been working towards throughout the last decade.
Sports Spotlight - Trinity Powerlifter's
By Ryan Farrell |  Posted: Wed 5:18 PM, Apr 24, 2019  |  Updated: Wed 11:32 PM, Apr 24, 2019 When you think of high school sports, Powerlifting is probably not the first thing that comes to mind. But, if you're at Trinity in Dickinson you know two names, Derek Dvorak and Cody Steffan. If you head to Trinity High School and watch the weight room, you'll witness two power lifters throwing around outstanding numbers.
Movie Talk: Pet Semetary: Dead is better
By Ryan Farrell, Staff Writer Recently, the movie theatre ushered in the next highly anticipated Stephen King adaptation, Pet Semetary. It can also be considered a remake of the 1989 film with the same name. The new take on the classic tale doesn’t bring anything new to the table which makes the film drag out. Jumpscares certainly take precedence over atmospheric and character-based horror and the film suffers as a result.
Coach DeKok Basketball Benefit
By Ryan Farrell |  Posted: Fri 4:20 PM, Apr 12, 2019 BISMARCK, N.D. - Brent DeKok knows the way from Bismarck to Rochester all too well. The St. Mary’s boys basketball coach has been to the Mayo Clinic a number of times for cancer treatment. This Sunday, a number of his peers have organized a Basketball All-Star Benefit for DeKok at Legacy High School.
Movie Talk: The Beach Bum: McConaughey falls flat
By Ryan Farrell, Staff Writer Another all-star cast has created another cinematic disappointment. The Beach Bum explores the life of someone who lives by his own rules but that is all it seems to bring. Scenes move from party to party with little context that makes the film seem more like an experience rather than a story. It fails to go in depth which makes it difficult to be invested. This party film was directed by Harmony Korine who’s known for creating films such as Spring Breakers.
Movie Talk: Us: You are your own worst enemy
By Ryan Farrell, Staff Writer Over this past weekend, Academy Award winner Jordan Peele released his highly anticipated second film, Us. His first film Get Out was met with critical praise which is why it received multiple Academy Award nominations and won the award for best original screenplay. This came as a surprise to some since most of Peele’s work was featured on Comedy Central. His next film once again tackles the horror genre and it appears that he has made another original piece.
Sports Spotlight: Luxon Glor
By Ryan Farrell |  Posted: Wed 4:36 PM, Mar 27, 2019 BISMARCK, N.D. - It’s hard to keep track of everything Luxon Glor has accomplished at the University of Mary. He's been named All American multiple times, he's broken school and conference records in numerous events, and he's been named the conference athlete of the year. Believe it or not, he still has a few more things he'd like to accomplish.
Bismarck native Britta Curl skates to victory with Wisconsin Badgers at NCAA championship
By Ryan Farrell |  Posted: Mon 9:53 PM, Mar 25, 2019 BISMARCK, N.D. - Bismarck native Britta Curl just finds a way to win. She was a champion throughout her career with the Bismarck Blizzard and she has done the same thing her freshman year in college. Curl and the Wisconsin Badgers won the NCAA championship with a 2-0 victory over the Minnesota Gophers on Sunday.
Thompson claims first-ever state title
By Ryan Farrell |  Posted: Sat 10:42 PM, Mar 16, 2019  |  Updated: Sat 11:11 PM, Mar 16, 2019 MINOT, N.D. - The Thompson Tommies defeated the Shiloh Christian Skyhawks 57-47 in overtime to take the class B state championship Saturday at the Minot State Dome. Hayden Overby led the way for the Tommies with 21 points to go along with 10 rebounds. Skyhawk's big man Macauley Young had a double-double with 25 points and 15 boards.
Sports Spotlight: Beulah boys basketball
By Ryan Farrell |  Posted: Wed 4:51 PM, Mar 13, 2019  |  Updated: Wed 10:08 PM, Mar 13, 2019 The final tournament of the high school basketball season is the class-B boys. Beulah beat Trinity by two points in the Region-7 title game to advance to state and now it's onto Minot for the "B", which is why the Miners are in this week's Sports Spotlight. The Beulah Miners last loss came back in late December. Their dominance since that game has the Miners thinking of a state championship.
Jamestown boys basketball wins first title since 1993
By Ryan Farrell  |  Posted: Sat 10:51 PM, Mar 09, 2019 BISMARCK The Jamestown Blue Jays defeated the Fargo Davies Eagles 66-49. It's the Blue Jays first state title since 1993. Blue Jays senior Mason Walters was named the Class A Tournament MVP. In the championship game, Walters had 19 points and 15 rebounds. Blue Jays junior and North Dakota State University-commit Boden Skunberg led all scorers with 23 points.
Century girls back-to-back State A champions
By Ryan Farrell |  Posted: Sat 8:07 PM, Mar 09, 2019  |  Updated: Sat 10:53 PM, Mar 09, 2019 BISMARCK, N.D. - The Century Patriots girls basketball team defeated the Devils Lake Firebirds 69-61 Saturday night at the Bismarck Event Center. Century Head Coach Ron Metz was happy to fill his season-long goal. "It feels awesome when you start a season, you have goals in mind.
Sports Spotlight: Lilly Keplin
By Ryan Farrell |  Posted: Wed 5:28 PM, Mar 06, 2019  |  Updated: Wed 7:28 PM, Mar 06, 2019 BISMARCK, N.D. - Lilly Keplin lead the Century Patriots to a victory in the West Region Championship game last week. Keplin scored 30 points in that contest and she's one of the best girls basketball players in North Dakota. It takes a special talent to contribute to a Class-A varsity basketball program for four years.
25 years of Worker Injury, Illness, and Fatality Case Data
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Sports Spotlight: Joe Jahner
By Ryan Farrell |  Posted: Wed 6:16 PM, Feb 27, 2019  |  Updated: Wed 8:20 PM, Feb 27, 2019 BISMARCK, N.D. - The West Region basketball tournament starts Thursday and the Bismarck Demons are the number two seed in the boys bracket. One of the main reasons they are one of the best teams in the West is because of the play of senior guard Joe Jahner. Jahner has scored over 1,000 points throughout his career as a Demon. A majority of those points have come from behind the arc.
Bismarck High hockey coaching staff steps down
By Ryan Farrell |  Posted: Sun 5:44 PM, Feb 24, 2019 BISMARCK, N.D. - Bismarck High head Hockey Coach Mike Peluso and the rest of his coaching staff are stepping away from the program after 11 years. With Peluso at the helm, the Demons had six title game appearances, six WDA Championships, over 200 wins, and the 2014 State Championship.
Sports Spotlight: Nicholas Brown
By Ryan Farrell |  Posted: Wed 3:50 PM, Feb 20, 2019  |  Updated: Wed 10:04 PM, Feb 20, 2019 The Century Patriots are the number one seed from the West Region for this weeks state tournament and a big part of their success is due to a Century senior. Nicholas Brown is one of the team captains for the Patriots. He's a player Troy Olson has watched flourish over the last four years. "He's grown every year, you know, he's really gotten better, he's gotten bigger, faster, and stronger.
Sports Spotlight: Ryan Ripplinger
By Ryan Farrell |  Posted: Wed 4:45 PM, Feb 13, 2019 BISMARCK, N.D. - The Bismarck Demons are on their way to the Fargodome for this year's state wrestling tournament. Ryan Ripplinger is one of the team's captains and when it's all said and done, he'll go down as one of the best wrestler in the programs outstanding history. Ripplinger is going for his fourth and final state championship. His success derives from his work ethic and determination.
People of USM: Maryann Russell
Posted on February 10, 2019 in Community By USM Free Press Photo courtesy of Maryann Russell By Ryan Farrell, Staff Writer Mental health has become a reoccuring conversation piece over the past couple of years. Since many students deal with stress from school, work, or both, universities have been offering more programs centered around benefitting mental health. This includes classes offered through the holistic health major.
Wentz Participates in 11 on 11 Drills
Carson Wentz hit another bench mark in his road to recovery. With the start of the regular season just under a month away, Carson has been a limited participant in Eagles training camp but has been taking on more of a work load each week. Wentz spoke to the media Monday morning after participating in 11 on 11 practices over the weekend. “I mean, not being out there was obviously frustrating. I think we talked a little bit about it last week, but I want to be out there every day.
North Dakota loses Little League Midwest Regional Championship
BISMARCK, N.D. - Late rally not enough for Team North Dakota. North Dakota loses Little League Midwest Regional Championship. The team from Fargo lost to Iowa 7 to 4. North Dakota was down 7 to 0 going into the last inning of play. Iowa will represent the Midwest at the Little League World Series in Williamsport, PA. Saturday's game was played in Indiana.
Killdeer native Austin Dufault joins Lakers coaching staff
Former Killdeer High School star Austin Dufault announced that he will be joining the Los Angeles Lakers as a Coaching Associate for the upcoming season. Dufault was Mr. Basketball for North Dakota in 2008. He went on to play college basketball at the University of Colorado from 2008–2012. After graduating, he traveled overseas to play Euro Basketball. During his career, Dufault has played in Czech Republic, Macedonia, Finland, France and Hungary.
Sports Spotlight: Murray & Andersen
When High School athletes become college athletes, it usually breaks up athletes who have been teammates for a long time but that is not the case for Killdeer duo in this week's Sports Spotlight. Trae Murray and Sydney Anderson just helped Class-B win a pair of Lion's All-Star Basketball games, but their time on the court together is not over yet. Anderson and Murray have been friends since they started playing basketball together at eight years old. "I mean we've had tons of sleepovers.
Sports Spotlight: Trace Jacobson
In North Dakota, you can compete on the varsity in high school in the seventh grade, if you're good enough.That's when Heart River graduate Trace Jacobson began golfing for Heart River High School. Jacobson has accomplished a lot during his prep career, but in this week's Sports Spotlight, we find out he is ready for the next step in his golfing life. Jacobson has been golfing here at Pheasant Country Club in South Heart for over 10 years.
Badlands BigSticks inaugural season
The Bismarck Larks played their first season in the Northwoods League last year and it was a big hit. Now, the Mountain Time zone has a collegiate wood-bat league to call its own. The Badlands BigSticks start their inaugural season May 25.
Sports Spotlight: Jarelle Miller
Jarelle Miller came to North Dakota to play college football. He's done with college, but he's not done with football. Miller is a standout defensive player for the Bismarck Bucks with a big influence in the community off the field as well. Miller is a linebacker from Orlando Florida, but how does a football player from the Sunshine State become a North Dakota resident?
Bismarck Bobcats brave the shave
Last year the Bismarck Bobcats raised around sixty-five hundred dollars for Brave the shave. Organizers are hopeful to see similar numbers this year. Saturday night kicked off with the whole arena honoring the children that are struggling with cancer. A young Cancer Survivor Aspen got to make a victory lap with a Brave the Shave flag. Then players, and coaches came out on the ice during intermissions to brave the shave themselves. "We have a lot of fun.
Marauders finish 4th at NCAA Division II Championship
The Marauders women's indoor track and field team had a strong performance at the NCAA Division II Championship finishing 4th. Head Coach Dennis Newell was pleased with the Marauders performance especially with a few alternates stepping up for the team.
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