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This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Ryan S. Noyce 1, Landon W. Westfall 2,†, Siobhan Fogarty 3, Karen Gilbert 2, Onesmo Mpanju 4, Helen Stillwell 3,‡, José Esparza 5, Bruce Daugherty 3, Fusataka Koide 2, David H.
Loading metrics Open Access Peer-reviewed Research Article Quinten Kieser, Ryan S. Noyce, Mira Shenouda, Y.-C. James Lin, David H. Evans Quinten Kieser, Ryan S. Noyce, Mira Shenouda, Y.-C. James Lin, David H. Evans Published: January 16, 2020 https://doi.org/10.1371/journal.pone.0228028 Figures Abstract Poxviruses replicate in cytoplasmic structures called factories and each factory begins as a single infecting particle.
scHPXV design strategy Given that the toxicity of modern VACV vaccines limits their use, and molecular analyses show that modern VACV vaccine strains share common ancestry with HPXV, we asked whether a HPXV-based vaccine might provide a safer alternative. Using the HPXV (strain WNR-76) sequence [4] we divided the 212,633 bp genome into 10-overlapping DNAs sharing ~1 kbp of flanking homology (Fig 1). Each fragment was synthesized and cloned into a bacterial vector.
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