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Ryunosuke Korenaga on Muck Rack

Ryunosuke Korenaga

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Binding characteristics of the doxepin E/Z‐isomers to the histamine H1 receptor revealed by receptor‐bound ligand analysis and molecular dynamics study

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By Hiroto Kaneko, Ryota Nakamura, Shinnosuke Kawai, Ryunosuke Korenaga
| Wiley Online Library Verified
1 INTRODUCTION When molecules with identical chemical formulae contain double bonds, their three-dimensional configurations may differ due to the inability of the double bonds to rotate. Geometric isomers belong to the category of stereoisomers and are often referred to as cis/trans or more generally E/Z-isomers. Geometric isomers can be generated during the chemical synthesis of small-molecule drugs.
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