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Ryusuke Hirama

As seen in: Cell Chemical Biology
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Articles

Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells

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By Azuma Kimura, Taro Toyoda, Mio Iwasaki, Ryusuke Hirama
| Cell Chemical Biology Verified
Highlights • WNT7B knockdown blocks compound-induced PPC proliferation • WNT7B-expressing feeder cells can induce PPC proliferation • Non-canonical Wnt/PKC pathway mediates PPC proliferation • YY1 phosphorylation regulates WNT7B expression in PPCs Summary The proliferation of human pancreatic progenitor cells (PPCs) is critical for developing cell therapies for diabetes.
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