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S. Cigall Kadoch on Muck Rack

S. Cigall Kadoch

As seen in: Nature
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Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer - Nature Genetics

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By Carman Man-Chung Li, Francesca Silvestri, Nomeda Girnius, Aviv Regev, Alyssa Cordes, S. Cigall Kadoch
| Nature Verified
Abstract Germline BRCA1 mutation carriers face a high breast cancer risk; however, the underlying mechanisms for this risk are not completely understood. Using a new genetically engineered mouse model of germline Brca1 heterozygosity, we demonstrate that early tumor onset in a Brca1 heterozygous background cannot be fully explained by the conventional ‘two-hit’ hypothesis, suggesting the existence of inherent tumor-promoting alterations in the Brca1 heterozygous state.
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