Peptide drugs have gained significant recognition in the pharmaceutical market due to their high specificity and efficacy, underscoring the importance of high-quality intermediates in peptide synthesis [1,2]. Among these, 9-fluorenylmethyloxycarbonyl (Fmoc) protected amino acids are widely used as essential building blocks for synthesizing high-purity peptides due to the stability of the Fmoc group under acidic conditions and its efficient removal under mild basic conditions [[3], [4], [5]].
