By P. Joshi, M. Barros, S. Tindal, M. Leuthold The concepts of intensified and continuous bioprocessing are central to current discussions in biomanufacturing, offering the potential for more efficient and cost-effective production across upstream and downstream processes. Continuous tangential flow filtration (TFF) and diafiltration are critical technologies for downstream processing. This study introduces an innovative flat sheet membrane device designed for TFF diafiltration.