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Saaid Safieddine

As seen in: Nature, MDPI, BioRxiv, Médecine Sciences
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Articles

Premiers succès de la thérapie génique dans la surdité congénitale DFNB9

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By Saaid Safieddine
| Médecine Sciences
Accueil Tous les numéros Volume 42 / Numéro 2 (Février 2026) Med Sci (Paris), 42 2 (2026) 121-124 Full HTML Numéro Med Sci (Paris) Volume 42, Numéro 2, Février 2026 Page(s) 121 - 124 Section Nouvelles DOI https://doi.org/10.1051/medsci/2026004 Publié en ligne 24 février 2026 Med Sci (Paris) 2026; 42 (2) : 121–124 Premiers succès de la thérapie génique dans la surdité congénitale DFNB9 a, b et c Université Paris Cité, Institut Pasteur, Assistance publique-Hôpitaux de Paris, Inserm, CNRS,...
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In utero adeno-associated virus (AAV)-mediated gene delivery targeting sensory and supporting cells in the embryonic mouse inner ear

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By Saaid Safieddine, Ghizlene Lahlou, Raphael Etournay
| BioRxiv
Abstract In vivo gene delivery to tissues using adeno-associated vector (AAVs) has revolutionized the field of gene therapy. Yet, while sensorineural hearing loss is one of the most common sensory disorders worldwide, gene therapy applied to the human inner ear is still in its infancy.
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Deafness: from genetic architecture to gene therapy - Nature Reviews Genetics

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By Christine Petit, Crystel Bonnet, Saaid Safieddine
| Nature Verified
Abstract Progress in deciphering the genetic architecture of human sensorineural hearing impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the elucidation of the molecular mechanisms underlying auditory system function, primarily in the cochlea, the mammalian hearing organ.
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