Saba Ataei Kachooei on Muck Rack

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More than half of annotated human miRNAs are never expressed at levels sufficient for biological function

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By Katherine Pillman, Philip Gregory, Saba Ataei Kachooei, Julie M Bracken
| biorxiv.org
Abstract MicroRNAs (miRNAs) are widely studied for their role in post-transcriptional gene regulation, often using exogenous overexpression systems to reveal their functions. However, such approaches may not accurately reflect endogenous miRNA activity due to the substantially higher expression levels achieved experimentally. To address this, we sought to determine the minimal endogenous expression threshold required for a miRNA to exert biologically significant effects.
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