Saba Rezaei-Lotfi on Muck Rack

Saba Rezaei-Lotfi

As seen in: Nature, Genome Biology
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Articles

Programmed genomic instability regulates neural transdifferentiation of human brain microvascular pericytes - Genome Biology

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By Saba Rezaei-Lotfi, Filip Vujovic, Mary Simonian, Neil Hunter, Ramin Farahani
| Genome Biology Verified
Genome Biology volume 22, Article number: 334 (2021) Cite this article Abstract Background Transdifferentiation describes transformation in vivo of specialized cells from one lineage into another. While there is extensive literature on forced induction of lineage reprogramming in vitro, endogenous mechanisms that govern transdifferentiation remain largely unknown.
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Genomic competition for noise reduction shaped evolutionary landscape of mir-4673

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By Ramin Farahani, Neil Hunter, Of Sydney, Saba Rezaei-Lotfi
| Nature Verified
Abstract The genomic platform that informs evolution of microRNA cascades remains unknown. Here we capitalised on the recent evolutionary trajectory of hominin-specific miRNA-4673, encoded in intron 4 of notch-1, to uncover the identity of one such precursor genomic element and the selective forces acting upon it. The miRNA targets genes that regulate Wnt/β-catenin signalling cascade.
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