Box 1 Representativeness Evidence shows that ethnic minorities, patients without medical coverage, and low income and rural populations are underrepresented, whereas women, older people, more educated patients, and patients with a greater burden of comorbidity are overrepresented in RCD.2223242526272829 If patients from underrepresented groups are present in the data, a substantial risk exists that they may be misrepresented as they receive fewer diagnostics tests and interventions,26 and...