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Sabnur Parvage on Muck Rack

Sabnur Parvage

As seen in: BioRxiv
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Articles

Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects

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By Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar, Sabnur Parvage
| BioRxiv
Abstract The clinical importance of iboga alkaloids lies in their efficacy in reversing drug addiction and modulating drug tolerance. However, due to safety concerns, their use is restricted to appropriate medical supervision. These alkaloids often cause severe hallucinogenic effects due to differential binding to various brain receptors and cardiotoxicity by blocking the human ether-a-go-go-related gene (hERG) potassium channel.
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