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Sabrina Barriere

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Articles

Optimizing Wilms tumor 1 thresholds for measurable residual disease monitoring in acute myeloid leukemia: Improved sensitivity and concordance with nucleophosmin 1 in a single‐center validation study

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By Sabrina Barriere, Céline Bourgne, Thomas Tassin, Anais Establie
| Wiley Online Library Verified
In acute myeloid leukemia (AML), measurable residual disease (MRD) assessment is essential for predicting relapse and guiding therapy decision-making. Nucleophosmin 1 (NPM1) mutations are reliable MRD markers but apply to only ∼30% of patients with AML. Wilms tumor 1 (WT1) expression monitoring is applicable to a broader population but the European LeukemiaNet (ELN) threshold of 50 WT1 copies per 104 ABL copies (0.5%) may be too high, which limits sensitivity.
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