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Sacha Bou Nafeh on Muck Rack

Sacha Bou Nafeh

As seen in: Nature
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Articles

Functional profiling of ovarian cancer models reveals Bcl-xL/NOTCH targeting to overcome resistance

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By Greta Gudoitytė, Olena Berkovska, Lukas M Orre, Elisabeth Moussaud-Lamodière, Rebecka Bergstrom, Johan Lindberg, Martin Haraldsson, Olli Kallioniemi, Ulrika Joneborg, Brinton Seashore-Ludlow, Sacha Bou Nafeh, Méline Louhaur, Josefin Fernebro
| Nature Verified
Abstract Platinum resistance remains a major therapeutic challenge in ovarian cancer (OC) and is one of the main causes leading to disease relapse and mortality. Although PARP inhibitors have improved outcomes for a subset of patients, most women continue to rely on platinum-taxol based chemotherapy and ultimately develop recurrent, treatment-resistant disease with limited further therapy options.
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