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Sadasivam Jeganathan on Muck Rack

Sadasivam Jeganathan

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Articles

A peptide with fine‐tuned flexibility inhibits NF‐Y transcription factor assembly

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By Sadasivam Jeganathan, CGC Dortmund GERMANY, Mathias Wendt, Sebastian Kiehstaller
| Color Research & Application Verified
Research Article A peptide with fine‐tuned flexibility inhibits NF‐Y transcription factor assembly Tom N. Grossmann Corresponding Author E-mail address: tom@grossmannlab.com VU Universtity Amsterdam, Chemistry and Pharmaceutical Sciences, De Boelelaan 1108, 1081 HZ Amsterdam, NETHERLANDS Search for more papers by this author PDF PDF Share Abstract Protein complex formation highly depends on the interplay between preorganization and flexibility of involved binding epitopes.
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Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity

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By Sadasivam Jeganathan, Angelika Heidrich, Jeremy Campos
| Nature Verified
The determination of affinities of nucleotides to Ras proteins is not a trivial exercise, which was originally the source of underestimates of the affinities of GTP and GDP4. A method which leads to estimates of the kinetic parameters as well as the affinity involves stopped-flow measurements of association of fluorescent nucleotides with nucleotide-free Ras followed by competiton between fluorescent and non-fluorescent nucleotides to obtain the parameters for the non-labelled substances3.
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