Sadhan Jana

Keywords phenotypic screening covalent inhibitor antibiotics activity-based protein profiling FabH MiaA PdxY Introduction Antibiotics are crucial for human medicine, yet the rise of antibiotic resistance jeopardizes their efficacy. To address this issue, one approach involves targeting the mechanisms behind resistance, such as proteins responsible for degrading or exporting antibiotics. Another method seeks to broaden the target scope by developing antibiotics that act on novel bacterial targets.

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