Skip To Main Content
Saeid Malek Zadeh on Muck Rack

Saeid Malek Zadeh

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Saeid Malek

Contact Saeid Malek, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient

|
By John Ni, Alison Berezuk, Peter Axerio-Cilies, Xing Zhu, Katharine Tuttle, Gethin Owen, Maria Tokuyama, Sriram Subramaniam, Saeid Malek Zadeh, Ryan Lynam
| Nature Verified
Abstract In 2024, an adolescent female in British Columbia was hospitalised presenting with severe symptoms including respiratory failure due to infection with a novel H5N1 influenza strain (BC24). Using cryogenic electron microscopy, we show here that the N169 α2,3-linked auto-glycan that is found in the sialic acid binding site of previously studied H5 hemagglutinin (HA) proteins is absent in purified BC24 HA protein, suggesting greatly reduced affinity for α2,3-linked sialosides.
Open in Who Shared Issue with article?
See all 1 articles