Sahabuddin Ahmed

Post-Traumatic Stress Disorder (PTSD) is a neuropsychiatric disorder with intrusive trauma-related memories, avoidance behavior, negative alterations in mood and cognition with hyperarousal symptoms, such as sleep disturbance that impair daily functioning [1]. It affects millions of people worldwide, and the distress caused by PTSD creates a social and economic burden on society.

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Abstract Abnormal development and function of the hippocampus are two of the most consistent findings in humans and rodents exposed to early life adversity, with males often being more affected than females. Using the limited bedding (LB) paradigm as a rodent model of early life adversity, we found that male adolescent mice that had been exposed to LB exhibit significant deficits in contextual fear conditioning and synaptic connectivity in the hippocampus, which are not observed in females.