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Sahida Afroz on Muck Rack

Sahida Afroz

As seen in: BioRxiv
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Articles

XPO1 inhibition modulates the Wnt/β-catenin signaling pathway to reduce colorectal cancer tumorigenesis.

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By Andrew Evans, Sahida Afroz, Dan Dixon, Alexa Magstadt
| BioRxiv
Abstract Colorectal Cancer (CRC) is the second leading cause of cancer-related death in the U.S. and high-risk individuals face a notably higher likelihood of developing CRC based on their genetic background. Hence, there is a compelling need for innovative chemopreventive treatments aimed at minimizing CRC tumorigenesis. Exportin 1 (XPO1; also referred to as CRM1) plays a pivotal role in transporting proteins from the nucleus to the cytoplasm.
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Characterization of novel role for Rab27B in autophagy regulation in colorectal cancer

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By Vikalp Vishwakarma, Andrew Evans, Sahida Afroz, Ranjan Preet
| BioRxiv
Abstract Introduction: Autophagy is a dynamic, multi-step process that cells use to degrade damaged, abnormal, and potentially harmful cellular substances. While autophagy is maintained at a basal level in all cells, it is activated at a higher level in many cancer cells and promotes tumor growth, anti-tumor immune response, and resistance to cancer therapy.
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