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Sai Balchand on Muck Rack

Sai Balchand

As seen in: PLOS, BioRxiv
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Articles

The CLIC/GEEC pathway regulates particle uptake and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages

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By Kathleen Candor, Lingmei Ding, Sai Balchand, Jason Hammonds, PLOS Pathogens
| PLOS
Materials and methods Human blood for the preparation of monocyte-derived macrophages and other experiments in this work was obtained from volunteer donors and was de-identified prior to handling by the investigators. Written informed consent was obtained from participants. Blood was collected under a protocol approved by the Cincinnati Children’s Hospital Institutional Review Board.
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The CLIC/GEEC pathway regulates particle endocytosis and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages

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By Kathleen Candor, Lingmei Ding, Jason Hammonds, Sai Balchand
| BioRxiv
Abstract HIV-1 particles are captured by the immunoglobulin superfamily member Siglec-1 on the surface of macrophages and dendritic cells, leading to particle internalization and facilitating trans-infection of CD4+ T cells. HIV-1-infected macrophages develop a unique intracellular compartment termed the virus-containing compartment (VCC) that exhibits characteristic markers of the late endosome and is enriched in components of the plasma membrane (PM).
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