Saïdou Mahmoudou

Highlights • Replication and shedding of the rVSVΔG-ZEBOV-GP vaccine not prolonged in children. • Replication-competent rVSVΔG-ZEBOV-GP induced sustainable and functional antibodies. • The rVSVΔG-ZEBOV-GP replication does not induce any unexpected adverse event. • Single dose of rVSVΔG-ZEBOV-GP is safe and immunogenic in Central African children. Abstract Unlike adults, children experienced stronger and longer vector replication in plasma and shedding in saliva following rVSVΔG-ZEBOV-GP vaccination.

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