Sajda Ashraf

1. Introduction Pyruvate kinase (PK) is a critical enzyme in glycolysis, the metabolic pathway that breaks down glucose to produce energy [1,2]. PK catalyzes the non-reversible, final step in the cytoplasmic metabolic pathway, converting phosphoenolpyruvate to pyruvate and adenosine triphosphate (ATP), using adenosine diphosphate (ADP) as a substrate (Figure 1) [3]. PK exists in four distinct isoforms in various vital organs of the human body, named PKL, PKR, PKM1, and PKM2 [4].

1. Introduction Newly emerged coronavirus outbreak of severe asymptomatic pneumonia has geographically been associated with the seafood market of south Chinese Wuhan city, primarily designated as 2019 novel coronavirus (Salata, Calistri, Parolin, & Palù, 2019; Seah & Agrawal, 2020; Hemida & Ba Abduallah, 2020; Chan et al. 2020).