Marina Barron Amira Asaad Kashuf Arooj Khan Salih Ali Wayne Chicken Mohamed Elamass Philip Idaewor Kingsley Osayi Firas Alkistawi Abdalla Saad Abdalla Al-Zawi Background: HER2 status is considered as an important prognostic and predictive factor in breast cancer treatment The cellular E-cadherin protein (encoded by the CDH1 gene) is expressed in the breast epithelial cells. Its function is functions is epithelial-to epithelial cell adhesion and epithelial-to-mesenchymal transition.