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Sam Bryce-Smith

As seen in: Nature, BioRxiv
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Articles by Sam Bryce-Smith

TDP-43 loss induces cryptic polyadenylation in ALS/FTD - Nature Neuroscience

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By Sam Bryce-Smith, Puja R Mehta, Francesca Mattedi, Yue Qi, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew J. Keuss, Michael Ward, Maria Secrier, Simone Barattucci
| Nature Verified
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TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD

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By Sam Bryce-Smith, Anna-Leigh Brown, Puja R Mehta, Francesca Mattedi
| BioRxiv
Abstract Nuclear depletion and cytoplasmic aggregation of the RNA binding protein TDP-43 is the hallmark of ALS, occurring in over 97% of cases. A key consequence of TDP-43 nuclear loss is the de-repression of cryptic exons. Whilst TDP-43 regulated cryptic splicing is increasingly well catalogued, cryptic alternative polyadenylation (APA) events, which define the 3' end of last exons, have been largely overlooked, especially when not associated with novel upstream splice junctions.
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Widespread 3' UTR splicing regulates expression of oncogene transcripts in sequence-dependent and independent manners

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By Jack Riley, Sam Bryce-Smith, Stuart Wilson, Cristina N Alexandru-Crivac
| BioRxiv
Abstract Background: Splicing in 3' untranslated regions (3' UTRs) is generally considered a signal to elicit transcript degradation via nonsense-mediated decay (NMD) due to the presence of an exon junction complex (EJC) downstream of the stop codon. However, 3' UTR intron (3UI)-containing transcripts are widespread and highly expressed in both normal tissues and cancers.
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Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data

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By Sam Bryce-Smith, Dominik Burri, Matthew Gazzara, Christina Herrmann
| BioRxiv
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