Michael Ward on Muck Rack

Michael Ward

Washington
As seen in: Arthritis & Rheumatology, Nature, The Washington Post, Wiley Online Library, CNBC, Frontiers, MDPI, SAGE Publishing, ZDNet, Emerging Themes in Epidemiology and
social/data science; statistics; Duke Emeritus Prof; Elected Fellow, Society for Political Methodology PredictiveHeuristics.com
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Articles

The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial - Nature Medicine

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By Catherine Mummery, Adam Simmons, Brady Burgess, Tuan Nguyen, Jingjing Gao, Ruchi Gupta, Caiyan Li, Sara Kenkare-Mitra, Arnon Rosenthal, Robert Paul, Michael Ward, Stephen Salloway, Gary Romano, Arthur J. Mayorga, Balasubrahmanyam Budda, Derk D. Purcell, Michael Grundman, Giacomo Salvadore
| Nature
Abstract Triggering receptor expressed on myeloid cells 2 (TREM2) regulates microglial function and is implicated in Alzheimer’s disease (AD) pathogenesis. Here we conducted a phase 2, randomized, double-blind, placebo-controlled trial of a humanized TREM2 agonistic monoclonal antibody in 381 participants with early AD. Participants were randomized (1:1:1:1) to receive AL002 (15 mg kg−1, 40 mg kg−1 or 60 mg kg−1) or placebo intravenously every 4 weeks for 48−96 weeks.
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TDP-43 loss induces cryptic polyadenylation in ALS/FTD - Nature Neuroscience

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By Sam Bryce-Smith, Puja R Mehta, Francesca Mattedi, Yue Qi, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew J. Keuss, Michael Ward, Maria Secrier, Simone Barattucci
| Nature
Abstract Nuclear depletion and cytoplasmic aggregation of the RNA-binding protein TDP-43 are cellular hallmarks of amyotrophic lateral sclerosis (ALS). TDP-43 nuclear loss causes de-repression of cryptic exons, yet cryptic alternative polyadenylation (APA) events have been largely overlooked.
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Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4

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By Roxan A Stephenson, Jordy Sepulveda, Kory R. Johnson, Adrian Lita, Jaanam Gopalakrishnan, Dominic J Acri, Alexandra Beilina, Linling Cheng, Linda Yang, Jessica Root, Michael Ward, Christian A. Combs, William C Skarnes, Mark R. Cookson, Han-Yu Shih, Mioara Larion, G. William Rebeck, Priyanka Narayan
| Cell Reports
Keywords lipid droplets triglycerides APOE microglia neuroinflammation Alzheimer's disease lipid metabolism motility iPSCs activation Research topic(s) CP: Neuroscience Introduction Neuroinflammation is central to the pathogenesis and progression of Alzheimer’s disease (AD).
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