Sam Butterworth

Abstract Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta-cells by islet-infiltrating cytotoxic lymphocytes and elevated intra-islet secretion of pro-inflammatory cytokines. However, the underlying pathophysiological mechanisms remain incompletely understood. We hypothesised that abnormal elevation of islet NAD, via activation of NAMPT, plays a key role in driving islet autoimmune processes, leading to beta-cell death in T1D.

1 Introduction The conversion of simple, aromatic heterocycles into complex 3D chiral molecules by reductive dearomatization is a highly efficient strategy for the synthesis of pharmaceutical intermediates and other compounds [1]. Chemical dearomatization strategies have improved regarding control of regio- and stereoselectivity; however, challenges still remain with respect to safe operation and economic viability [-–7].

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