1. Increased Protection for Endangered Species The US EPA implemented a new policy on January 11, 2022. Prior to registering any new conventional active ingredient (AI), the US EPA will evaluate potential effects of the AI on federally threatened or endangered species and their designated critical habitats. In the past, ESA analysis was not required for all applications of new AI’s. Over 1,300 species are listed as either endangered or threatened in the US under the Endangered Species Act.