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Samhita Chaudhuri

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Articles

Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy - Nature Communications

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By Nuo Sun, Mingchong Yang, Shiori Sekine, Kedryn K. Baskin, Harpreet Singh, Samhita Chaudhuri
| Nature Verified
Abstract The healthy heart relies on mitochondrial fatty acid β-oxidation (FAO) to sustain its high energy demands. FAO deficiencies can cause muscle weakness, cardiomyopathy, and, in severe cases, neonatal/infantile mortality. Although FAO deficits are thought to induce mitochondrial stress and activate mitophagy, a quality control mechanism that eliminates damaged mitochondria, the mechanistic link in the heart remains unclear.
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