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Samira Anbari on Muck Rack

Samira Anbari

As seen in: Nature, Wiley Online Library
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Articles

Identifying biomarkers for treatment of uveal melanoma by T cell engager using a QSP model - npj Systems Biology and Applications

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By Samira Anbari, Hanwen Wang, Theinmozhi Arulraj, Jun Wang
| Nature Verified
Abstract Uveal melanoma (UM), the primary intraocular tumor in adults, arises from eye melanocytes and poses a significant threat to vision and health. Despite its rarity, UM is concerning due to its high potential for liver metastasis, resulting in a median survival of about a year after detection. Unlike cutaneous melanoma, UM responds poorly to immune checkpoint inhibition (ICI) due to its low tumor mutational burden and PD-1/PD-L1 expression.
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Quantitative systems pharmacology modeling of macrophage‐targeted therapy combined with PD‐L1 inhibition in advanced NSCLC

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By Hanwen Wang, Theinmozhi Arulraj, Samira Anbari, Aleksander S. Popel
| Wiley Online Library Verified
WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? QSP models have shown their potential to make efficacy predictions for novel drug combinations in immuno-oncology. Macrophage-targeted treatments have shown a promising effect on tumor eradication in mice. WHAT QUESTION DID THIS STUDY ADDRESS? With a quantitative systems pharmacology model, this study predicts how macrophage-targeted therapies would perform in combination with immunotherapy. WHAT DOES THIS STUDY ADD TO OUR KNOWLEDGE?
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