Samruddhi Shembekar on Muck Rack

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Myosin-19 and Miro regulate mitochondria-endoplasmatic reticulum contacts and mitochondria inner membrane architecture

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By Ulrike Honnert, Aya Attia, Katarzyna Majstrowicz, Samruddhi Shembekar
| biorxiv.org
Abstract Mitochondrial dynamics is important for cellular health and includes morphology, fusion, fission, vesicle formation, transport and contact formation with other organelles. Myosin XIX (Myo19) is an actin-based motor which competes with TRAK1/2 adaptors of microtubule-based motors for binding to the outer mitochondrial membrane receptors Mitochondrial Rho GTPases 1/2 (Miro). Currently, it is poorly understood how Myo19 contributes to mitochondrial dynamics.
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